从炎症与代谢视角探讨PCSK9、DPP-4在冠心病中作用的研究进展
吴国庆

内蒙古民族大学，内蒙古自治区，028000；

摘要：冠心病是一种复杂的炎症代谢性疾病，发生与进展同脂代谢紊乱、免疫炎症反应等病理生理过程有关。新近证据表明，PCSK9与DPP-4在炎症调节、免疫细胞活化、脂肪组织功能障碍等方面发挥着重要作用，是当前心血管代谢领域的研究热点。本文系统综述PCSK9与DPP-4在冠心病中的作用进展，特别聚焦二者通过“炎症-代谢”轴产生协同效应，共享上游调控信号，分别通过调控共有免疫与适应性免疫来促进动脉粥样硬化，并与心外膜脂肪组织形成病理对话，旨在为冠心病的精准防治提供新视角。

关键词：炎症；代谢；PCSK9；DPP-4；冠心病

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