MRF在鼻咽癌移植瘤模型定量成像的初步研究
刘勤敏1 罗永进2

1赣南医科大学第一附属医院，江西赣州，341000；

2安远县人民医院CT/MR室，江西安远，342100；

摘要：目的：探讨MRF技术在鼻咽癌裸鼠移植瘤模型定量成像方面的应用。方法：通过构建鼻咽癌裸鼠移植瘤模型并对模型进行磁共振指纹（Magnetic resonance fingerprinting，MRF）成像，生成纵向弛豫加权成像（T1-Weighted Image，T1WI）和横向弛豫加权成像（T2-Weighted Image，T2WI）定量图；对移植瘤及肝组织进行感兴趣区（Region of Interest，ROI）勾画，计算T1和T2值，并进行统计分析，P≤0.05为差异有统计学意义。结果：本研究成功构建了鼻咽癌移植瘤模型。MRF成像定量分析显示：移植瘤的T1值为1630±70，肝脏T1值为952±37，移植瘤的T2值为147±13，肝脏T2值为65±5，差异有统计学意义（P＜0.001）。结论：MRF成像技术在鼻咽癌移植瘤定量成像方面有一定的价值。

关键词：MRF技术；定量；鼻咽癌；移植瘤

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