sFlt-1/PLGF比值在子痫前期的研究进展
王鸿运1 徐爱群2通讯作者

1滨州医学院第二临床医学院、滨州医学院烟台附属医院，山东烟台，264100；

2滨州医学院烟台附属医院，山东烟台，264100；

摘要：子痫前期（PE）是以胎盘缺血缺氧导致血管生成失衡为核心的妊娠并发症，全球发病率5%~8%。传统诊断依赖血压和蛋白尿检测，亟需更精准标志物。研究表明，sFlt-1/PLGF比值具有重要预测价值：sFlt-1通过拮抗VEGF/PLGF通路抑制胎盘血管生成，PLGF下降加重内皮损伤，比值升高与胎盘缺氧正相关。有数据显示，该比值阴性预测值达99.3%（排除PE），阳性预测值36.7%（预测发病），结合自动化检测技术显著提升标准化水平。联合检测可优化效能，如联合子宫动脉搏动指数（UtA-PI）使检出率达82.4%，联用sEng可将重度PE预测敏感性提升至94%。但临床应用仍面临孕周差异（早/晚发型PE）等挑战，联合方案尚无统一标准。本文系统梳理sFlt-1/PLGF比值的研究进展，为PE早期防治提供理论依据。

关键词：子痫前期；可溶性酪氨酸激酶-1；胎盘生长因子；预测

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