甘油三酯葡萄糖指数与心血管死亡的相关性研究
黎嘉豪 蒲祥元

浙江大学医学院附属第一医院，浙江省杭州市，310003；

摘要：甘油三酯葡萄糖指数（TyG指数）作为一种胰岛素抵抗的简易标志物，近年来在心血管风险的预测、评估方面愈发受到重视。本综述系统总结了TyG指数与心血管死亡的相关性。研究表明，TyG指数升高与全因死亡率、心血管死亡率显著相关，其关联模式存在异质性：包括J型（临界值8.5–9.83）、U型（风险区间8.83–9.06）、线性正相关（每单位增加风险升高15%–96%）及反向L型。机制研究提示，TyG指数可能反映了胰岛素抵抗诱导的内皮功能障碍、氧化应激、钙信号紊乱及炎症反应促进心血管损伤。未来需通过多中心队列验证TyG的特异性临界值，探索其动态变化及多标志物联合应用价值，以提升心血管死亡风险分层精度。

关键词：甘油三酯葡萄糖指数；胰岛素抵抗；心血管死亡；风险评估；代谢紊乱；预后

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