IL-1、TNF-α基因多态性与种植体周围炎感性的相关性研究
周琼 张强 娜荷雅 刘立杰

北京大学第三医院北方院区 口腔科，北京海淀，100089；

摘要：随着口腔种植技术的快速发展，种植体周围炎(Peri-Implantitis,PI)的发生成为影响种植成功率的重要因素。促炎因子白介素-1 （IL-1）和肿瘤坏死因子α (TNF-α)在种植体骨整合过程宿主免疫反应和骨代谢中发挥重要作用。近年来IL-1α、IL-1β和TNF-α的基因多态性与种植体周围疾病相关性研究已成为研究热点之一。IL-1和TNF-α基因多态性在PI的发病机制中发挥关键作用，不同的基因型通过调节炎症反应，可能导致个体在PI方面的易感性差异。为了进一步深入了解IL-1和TNF-α的基因多态性与PI易感性之间的关系，本文综述了近年来国内外其与PI的相关性研究报道，旨在探讨IL-1和TNF-α基因多态性对PI发生发展的作用机制，为PI的研究及预防提供理论基础。

关键词：基因多态性；IL-1；TNF-α；种植体周围炎(PI)；遗传易感性

参考文献

[1]吴东潮,何东宁,余飞燕,等.PI免疫应答机制的研究进展[J].口腔颌面修复学杂,2024,25(05):371-377+388.

[2]Galindo P, López J, Caba M, et al. Morphological and immunophenotypical differences between chronic periodontitis and peri-implantitis - a cross-sectional study. Eur J Oral Implantol. 2017;10(4):453-463.

[3]Chen X, Zhao Y. Genetic Involvement in Dental Implant Failure: Association With Polymorphisms of Genes Modulating Inflammatory Responses and Bone Metabolism. J Oral Implantol. 2019; 45(4):318– 26.

[4]Jin Q, Teng F, Cheng Z. Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis. PLoS One. 2021 Oct 5;16(10):e0258138.

[5]Eguia Del Valle A, Lopez-Vicente J, Martinez-Conde R, et al. Current understanding of genetic polymorphisms as biomarkers for risk of biological complications in implantology. J Clin Exp Dent. 2018; 10(10):e1029–e39.

[6]Wang J, Shi YG, Wang GC,et al. The association between interleukin-1 polymorphisms and their protein expression in Chinese Han patients with breast cancer. Mol Genet Genomic Med. 2019; 7(8):e804.

[7]Mohammadi H, Roochi MM, Sadeghi M, et al. Association between Interleukin-1 Polymorphisms and Susceptibility to Dental Peri-Implant Disease: A Meta-Analysis. Pathogens. 2021 Dec 9;10(12):1600.

[8]Yilihamujiang H, Ni X, Yu M, Dong S, Mei L, Zheng Y, Cheng L, Pang N. Serum TNF-α level and probing depth as a combined indicator for peri-implant disease. Braz J Med Biol Res. 2024 Jan 22;57:e12989.