心脏异种移植从概念走向临床
杨晶月¹ 叶文学²

1 苏州大学附属第一医院，江苏苏州，215006；

2 苏州大学附属第一医院心脏大血管外科，江苏苏州，215006；

摘要：心脏移植是各种疾病所导致的终末期心力衰竭患者的最佳治疗方法，供体器官严重短缺限制了其广泛应用。异种心脏异种移植有望解决心脏供体稀缺问题，但仍面临诸多挑战。近年来，基因编辑技术的发展和免疫抑制药的研发，为异种心脏移植的临床应用奠定新的基础。本文对异种心脏移植现状、面临问题及未来发展等方面进行综述，综合叙述了近年来异种移植仍存在的问题，为异种心脏移植的进一步研究及临床应用提供思考。

关键词：心脏异种移植；免疫抑制；转基因编辑

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