化妆品原料密蒙花提取物的局部毒性研究
朱志贤¹ 陈国宝¹ 陈保华²

1.甘肃泛植制药有限公司，甘肃 兰州 730000

2.兰州大学， 甘肃 兰州 730000

摘要：目的：考察密蒙花提取物在护肤中的安全性。利用鼠皮肤光毒、兔急性眼刺激性、皮肤刺激性安全性相关实验表明该提取物对皮肤无刺激性、变态反应与光毒性，无急性眼刺激性。结论：密蒙花提取物安全性较好。

关键词：密蒙花；护肤功效；安全性

Efficacy and Safety Evaluation of Buddleja Officinalis Extract in Skincare

ZHU Zhixian¹,CHEN Guobao¹, CHEN Baohua².

1.Gansu Fanzhi Pharmaceutical Co., Ltd., Gansu, Lanzhou, 730000, China;

2.Lanzhou University, Gansu, Lanzhou, 730000, China

Objective: To investigate the safety of extracts from Mimenghua in skincare. Experiments using mouse skin phototoxicity, rabbit acute eye irritation, and skin irritation safety have shown that the extract has no skin irritation, allergic reactions, or phototoxicity, and no acute eye irritation. Conclusion: The extract of Mimenghua has good safety.

Keywords: Mimenghua; Skincare benefits; Security

参考文献；

[1]Long Z H, Li B Y, Wang Q Y, et al. A new he xenol glycoside compound in Buddleja officinal is [J]. Chinese Journal of Chinese Materia Med ica,2021,46(23):6178-6184. 

[2]Chen X F,Yuan L B,Gu X P.Research progress and quality marker prediction and analysis of chemical composition and pharmacological activ ity of Buddleja officinalis [J].China Journal of Traditional Chinese Medicine Information,20 22,29(11):141-148.) 

[3]LI G, CHEN X, ZHANG D Y, et al.Traditional application and modern research of four Dai be auty and skin care characteristic plant resour ces[J].China Cosmetics,2021(11):117-1 21. 

[4]LI Y S. Research on the preparation process and efficacy evaluation of sunscreen with mix ed extract of Buddleja officinalis and fragran ce reduction based on liposome technology[D].H eilongjiang Academy of Traditional Chinese Med icine,2022.