circRNA促进口腔鳞状细胞癌的增值、侵袭和迁移
张寒

中南大学湘雅医学院，湖南省长沙市，410000；

摘要：口腔鳞状细胞癌（oral squamous cell carcinoma，OSCC）是头颈部最常见的恶性肿瘤，临床上包括牙龈癌、舌癌、软硬腭癌、口底癌等。尽管手术切除联合化疗和放疗的治疗方法已广泛应用，但OSCC仍总体预后不佳，且近20年来没有任何明显的进展。发生转移是OSCC预后不良的重要指标，大多数转移性OSCC患者生存期仅不到一年。因此，探究OSCC增殖侵袭和迁移的潜在分子机制可以为OSCC治疗开拓新的思路，提供新的潜在治疗靶点。环状RNA（circRNA）是内源性非编码RNA的新兴亚群，大量研究表明，circRNA通过circRNA-miRNA-mRNA网络在癌症发生发展中发挥重要作用。越来越多的实验证明，一些circRNA能促进OSCC的进展。circRNA有望作为OSCC转移、复发的潜在标志物，为其诊断、治疗提供新思路。

关键词：癌细胞迁移；环状RNA；癌症标志物

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