Μ阿片和ghrelin受体杂合肽的设计及镇痛作用的研究
马莹 李臣鸿^*

中南民族大学，湖北省武汉市，430074；

摘要：本研究设计了一种新型的杂合肽ghrelin(1-5)-EM1，结合了内吗啡肽和ghrelin的活性片段。实验结果表明，ghrelin(1-5)-EM1在CFA慢性炎症痛和醋酸扭体急性内脏痛模型中均表现出剂量和时间依赖性的镇痛效果。其镇痛作用可被阿片受体拮抗剂纳洛酮和ghrelin受体拮抗剂DLS完全拮抗，说明其通过这两种受体机制产生镇痛效应，在有效剂量范围内不会显著影响大鼠的运动活性或胃肠运动，未表现出明显的副作用。该杂合肽为开发新型镇痛药物提供了新的思路，并可能成为解决阿片类药物副作用的潜在替代方案。

关键词：炎性痛；杂合肽μ-阿片/ghrelin受体

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