瘤内微生物对细胞治疗的影响和作用机制
顾佩佩

湖南工业大学 生物医学纳米材料与器件湖南省重点实验室，湖南株洲，412007；

摘要：近年来，瘤内微生物群被认为是肿瘤微环境（TME）的关键组成部分，并且在肿瘤的发生、进展及治疗应答中发挥重要作用。微生物不仅影响肿瘤细胞的生物学行为，还可通过代谢调控、免疫信号传导及炎症调节深度重塑TME。此外，瘤内微生物对细胞治疗疗效具有显著影响，特定微生物能够增强T细胞活化，提高抗肿瘤免疫效应，而某些致病菌则可能促进免疫逃逸，削弱细胞治疗效果。本文综述了瘤内微生物的组成、功能及其在实体瘤发展中的作用，并重点探讨微生物如何调节TME，从而影响细胞治疗的有效性。深入理解微生物-宿主互作对细胞治疗的影响，有助于优化个性化癌症免疫治疗策略，为精准医学提供新思路。

关键词：瘤内微生物；肿瘤微环境调控；免疫逃逸；细胞治疗

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