器官芯片技术：研究心脏疾病的新方法
周美杉

东南大学，江苏省南京市，210000；

摘要：器官芯片越来越多地应用于心血管病理生理学研究中作为传统体外细胞培养的替代品。微流控心脏芯片可以概括心脏组织水平的功能以及细胞和细胞外基质之间的通信，还可以进行更高通量的研究，有利于药物筛选。本篇综述回顾了心脏芯片制造，心肌细胞功能化，以及药物筛选和疾病建模的临床应用方面的最新进展和挑战。并在最后总结了心脏器官芯片平台的当前挑战和未来前景。

关键词：器官芯片；心脏疾病

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