超短波辅助治疗急性胰腺炎的临床观察
叶伟恒 胡耀光 黄明华通讯作者

佛山市南海区第六人民医院 普外科，广东佛山，528248；

摘要：[目的]观察超短波辅助治疗急性胰腺炎（acute pancreatitis, AP）的临床疗效。[方法]收集佛山市南海区第六人民医院普外科2021年6月至2022年12月收治入院的60例AP患者进行回顾性分析。常规保守治疗为对照组，而有超短波辅助的保守治疗则为实验组，其中实验组28例，对照组32例。比较两组患者C反应蛋白（C-reactive protein, CRP）、中性粒细胞与淋巴细胞比值（neutrophil to lymphocyte ratio, NLR）、住院天数、住院费用。[结果]经治疗后，实验组的CRP为25.99±12.61 mg/mL、NLR为5.00±1.09，对照组的CRP为34.76±17.73 mg/mL、NLR为5.97±1.84，差异有统计学意义（P < 0.05）。实验组的住院天数为8.23±3.01天、住院费用为9585.35±2723.76元，对照组的住院天数为9.23±3.41天、住院费用为9306.45±4298.42元，两组住院天数和费用差异无统计学意义（P > 0.05）。[结论]超短波辅助治疗急性胰腺炎（AP），更好地降低腹部炎症反应，无明显增加住院费用和延长住院天数，具有临床推广意义。

关键词：超短波辅助治疗；急性胰腺炎；C反应蛋白；中性粒细胞与淋巴细胞比值

参考文献

[1]van Santvoort HC, Bakker OJ, Ali UA, Am S, et al. A conservative and minimally invasive approach to necrotizing pancreatitis improves outcome[J]. Gastroenterology, 2011, 141(5):1254–1263.

[2]Boxhoorn L, Voermans RP, Bouwense SA, et al. Acute pancre-atitis[J]. Lancet, 2020, 396(10252): 726-734.

[3]Hines OJ, Pandol SJ. Management of severe acute pancreatitis[J]. BMJ, 2019, 367(8): l6227.

[4]李秋革,李贺芝.超短波在临床疾病治疗中的研究进展[J].中国社区医师(医学专业),2011,13(34):17-18.

[5]李非,曹锋.中国急性胰腺炎诊治指南(2021)[J].中国实用外科杂志,2021,41(07):739-746.

[6]Garber A, Frakes C, Chahal P. Mechanisms and management of acute pancreatitis[J]. Gastroenterol Res Pract, 2018, 80(2):6218798.

[7]Roberts SE, Morrison-Rees S, John A, et al. The incidenceand aetiology of a.cute pancreatitis across Europe[J]. Pancreatology, 2017, 17(18): 155-65.

[8]Petrov MS, Yadav D. Global epidemiology and holisticprevention of pancreatitis[J]. Nat Rev Gastroenterol Hepatol, 2019, 16(3): 175-84.

[9]Li CL, Jiang M, Xu LG. The global, regional, and national burden of acute pancreatitis in 204 countries and territories, 1990-2019[J]. BMC Gastroenterol. 2021, 21(1): 332.

[10]Peery AF, Crockett SD, Gangarosa LM, et al. Burden of gastrointestinal, liver, and pancreatic diseases in the UnitedStates[J]. Gastroenterology, 2015, 149(14): 1731-1741.

[11]van Brunschot S, van Grinsven J, Voermans RP, et al. Transluminal endoscopic step-up approach versus minimally invasive surgical step-up approach in patients with infected necrotising pancreatitis (TENSION trial): design and rationale of a randomised controlled multicenter trial [J]. BMC Gastroenterol, 2013, 13(2):161.

[12]Bang JY, Arnoletti JP, Holt BA, et al. An endoscopic transluminal approach, compared with minimally invasive surgery, reduces complications and costs for patients with necrotizing pancreatitis[J]. Gastroenterology, 2019, 156(6):1027-1240.

[13]Food and Drug Administration, HHS. Physical Medicine Devices; Reclassification of Shortwave Diathermy for All Other Uses, Henceforth To Be Known as Nonthermal Shortwave Therapy. Final order; technical correction[M]. Fed Regist, 2015, 80(197):61298-302.

[14]黄海良.超短波治疗仪辅助生长抑素在急性胰腺炎治疗中的效果[J].江西医药,2021,56(12):2197-2198+2204.

[15]黄静茹,黄志浩,卢丽君.超短波与运动疗法治疗老年膝关节骨性关节炎患者的疗效分析[J].现代医学与健康研究电子杂志,2022,6(7):80-82.

[16]李娟，黎贵湘．极超短波治疗仪对急性胰腺炎血清炎性因子的影响及疗效观察[J]．实用医院临床杂志,2016,4(13):198-199．

[17]王万朋,张岩,刘海燕,等．Th1和Th2细胞与急性胰腺炎严重程度的关系[J]．中华急诊医学杂志,2019,28(7):880-885.

[18]李文龙,苏纪荣．急性胰腺炎发病机制研究进展[J]．基层医学论坛,2007,11(8):749-750．

[19]Kim H, Kim H J, Kang J H, et al. Evaluation of serum C-reactive protein and high mobility group box 1 concentrations in 22 dogs with acute pancreatitis: a pilot study[J]. The Veterinary quarterly, 2019, 39(1): 1-12.

[20]WitoldKolber, Beata, et al. Neutrophil to lymphocyte ratio at the early phase of acute pancreatitis correlates with serum urokinase-type plasminogen activator receptor and interleukin 6 and predicts organ failure[J]. Folia medica Cracoviensia, 58(4): 57-74.

[21]Abayl B, GenDal G, DeIrmencio Lu. Correlation between neutrophil/lymphocyte ratio and Ranson score in acute pancreatitis[J]. Journal of Clinical Laboratory Analysis, 2018, 32(6):  22437-22442.

[22]陈梦婷,余清萍,唐俊,等.血清PCT、NLR及CRP水平与急性胰腺炎严重程度的相关性[J].西部医学,2021,33(12):1849-1853.

[23]谢文秀,张春燕,常艳.血液相关标志物与急性胰腺炎病情严重程度的相关性研究[J]．中国临床医生杂志,2020,48(11):29-32.