胃腺癌新亚型：异时性混合型胃底腺幽门腺粘膜型腺癌
张一帆1 王心烁1 范广琰1 周成军^2*

1山东大学，山东济南，250012；

2山东大学第二医院，山东济南，250033；

摘要：一位64岁男性在因同时性多发性早期胃癌(SMEGC)接受内镜下粘膜剥离术(ESD)后，在常规胃镜复查中发现贲门处出现新的浅表隆起型病变。该病变的镜下病理特征与内镜特征高度一致，且具有独特的消化内镜、组织病理学和免疫组化特征。形态学上，病变显示出向小凹上皮、胃底腺和幽门腺分化的趋势，而且病变表面可见乳头状结构。免疫组化结果显示，小凹型腺癌对MUC5AC呈阳性反应；胃底腺型腺癌(GA-FG)对pepsinogen-I和MUC6呈阳性反应；幽门腺型腺癌(GA-PG)对MUC6呈阳性反应。此外，组织学和血清学检测均未发现幽门螺杆菌(H.pylori)感染。我们首次报道了1例H.pylori阴性的伴随型同时性多发性早期胃癌伴发异时性混合型胃底腺幽门腺粘膜型腺癌病例。

关键词：早期胃癌；胃型；异时性胃癌；同时性多发性早期胃癌；混合型胃底腺幽门腺粘膜型腺癌

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