早期饥饿暴露对心血管与代谢健康的跨代影响
黄嘉美

中山大学附属第八医院，广东深圳，518000；

摘要：生命早期饥饿暴露对成年期心血管健康的影响已成为发育起源研究的重要领域。基于健康与疾病的发育起源理论，胎儿期或儿童期经历严重营养不良不仅会显著增加暴露人群成年后心血管疾病风险，并且可将表观遗传调控和代谢编程作为一种可能的跨代载体对后代心血管及代谢健康产生跨代影响。本文旨在综合阐述生命早期饥饿暴露对心血管与代谢健康跨代影响的流行病学研究和相关机制研究的最新进展，以期为预防生命早期营养不良、减少心血管与代谢疾病在多代间的发生提供科学依据，强调需要将饥饿暴露的家族史纳入心血管风险评估体系，并建立多代健康档案以实现早期干预。未来的研究应整合跨代队列研究和多组学技术，揭示关键的表观遗传通路，开发阻断代谢风险跨代传递的精准策略。

关键词：早期饥饿暴露；心血管与代谢；跨代；表观遗传

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