m6A甲基化在非酒精性脂肪肝中的研究进展
浦舒迪1 刘怡辰1 张晓坤1 何家迪2 通讯作者 黄曦1*

1昆明医科大学基础医学院，云南昆明，650500；

2深圳大学总医院麻醉科，广东深圳，518055；

摘要：非酒精性脂肪肝病（NAFLD）是一种常见的慢性肝病，其发病机制复杂，涉及多种因素；m6A(N6-methyladenosine，m6A)修饰是腺嘌呤（A）第六个 N 原子发生甲基化，是RNA最常见的甲基化修饰。越来越多的研究表明，m6A修饰在NAFLD的进展中具有重要作用。本文主要通过m6A写入器、擦除器和阅读器在NAFLD中的作用以及m6A通过影响脂质代谢、自噬以及药物作用方面，阐述了其与疾病的关系。

关键词：非酒精性脂肪肝；m6A甲基化

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