静息态功能磁共振与双下肢静脉血栓相关研究文献综述
郑利

山西医科大学，山西太原，030000；

摘要：静息态功能磁共振成像（rs-fMRI）作为非侵入技术，可无创勾勒大脑内在功能网络，展现自发低频BOLD信号波动下的功能连接。双下肢静脉血栓（DVT）是常见血管病，除影响外周循环，血栓脱落致肺栓塞是主要威胁。近年发现其与中枢神经系统功能有潜在关联，涉及疼痛、情绪等多方面。本文综述rs-fMRI原理等，回顾其在多病研究进展，探讨DVT致脑功能改变机制，分析研究现状，提出引入评估的可行方向以供跨学科参考。

关键词：静息态功能磁共振；双下肢静脉血栓；功能连接；默认模式网络；神经-血管交互

参考文献

[1]Biswal B, Yetkin FZ, Haughton VM, Hyde JS. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med. 1995;34(4):537-541.

[2]Raichle ME et al. A default mode of brain function. PNAS. 2001;98(2):676-682.

[3]Kurz A, et al. Altered brain connectivity in patients with chronic venous insufficiency. J Vasc Surg Venous Lymphat Disord. 2017;5(2):163-171.

[4]Zhang Y, et al. Cerebral effects of acute pulmonary embolism in a rat model. Exp Neurol. 2020;328:113254.

[5]Mason S, et al. Resting-state fMRI reveals cognitive-related network changes after major surgery. Br J Anaesth. 2018;120(3):526-535.

[6]Baliki MN, et al. Chronic pain and the emotional brain: specific brain activity associated with spontaneous pain intensity. J Neurosci. 2008;28(22):12165-12173.

[7]Sheline YI, et al. Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus. PNAS. 2010;107(24):11020-11025.

[8]Tong Y, Huang X, Gao Q, Qi CX, Shen Y. [Fractional amplitude of low-frequency fluctuations in retinal vein occlusion: a resting-state fMRI study]. Zhonghua Yan Ke Za Zhi. 2020 Apr 11;56(4):266-271. Chinese.