基于网络药理学的罗汉果陈皮止咳化痰研究——活性分、作用靶点及通路预测分析
陈蔓晗1 林小洁2 陈沛洪2（通讯作者）

1广东药科大学中医学院，广东汕头，515000；

2汕头大学医学院第二附属医院药学部，广东汕头，515000；

摘要：网络药理学探讨罗汉果和陈皮止咳化痰的作用机制。方法：采用网络药理学与分子对接技术，筛选两药入血活性成分，获取咳嗽咳痰相关靶点，经富集分析、PPI网络构建后，对核心成分与关键靶点进行对接验证。结果:入血成分16个。对接结果显示罗汉果陈皮入血成分与AKT1,TNF,CHRNA7,PTGS2有较好的结合活性。结论:罗汉果陈皮可能通过抑制炎症的发生和舒张支气管平滑肌来发挥止咳化痰的作用，该结果可为后续研究提供参考方向。

关键词：止咳化痰；网络药理学；罗汉果；陈皮

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